Contraception

Ohana Provides Healthier Contraceptive Options

Hormonal contraceptive pills were first developed in the 1950s. It’s time to evolve these methods.

In the U.S., half of all pregnancies are unintended; yet 60% of women report actively using birth control when they conceived. The majority of contraception methods used by couples is controlled by the woman, with 50% opting to use methods that interfere with normal hormonal balances.

Short-term side effects from hormonal contraceptive options include migraines, weight gain, mood changes, decreased libido, and nausea, among others. Serious possible side effects include an increased risk of certain cancers, gastrointestinal tract diseases, and cardiovascular events, such as blood clots, deep vein thrombosis, stroke, or heart attack. The long-term implications of persistently elevated hormone levels are likely inadequately characterized. At the same time, men have no pharmaceutical contraceptives available to them, despite half of men indicating they would be interested in an option.

Ohana’s Solution

First Non-hormonal Pharmaceutical Contraceptive for Men and Women

Ohana is developing contraceptives for both men and women that fulfill many key attributes that people are seeking in a contraceptive agent:

  1. Non-hormonal: enables people to avoid the unwanted side effects of hormonal birth control medications
  2. Long lasting: prevents conception with a single dose every three months
  3. Reversible: allows people the choice of fertility
  4. Non-invasive: does not require an implant or surgical procedure

In preclinical mouse models, our lead candidate blocked sperm activity, resulting in an inability for the sperm to fertilize an egg, in vitro.