At Ohana, our team of researchers has pioneered new and innovative technologies to advance the field of reproductive medicine and spermatogenesis, specifically by addressing:
• Single-cell heterogeneity in sperm. Within the average 100 million sperm per ejaculate, significant variations exist both at the molecular and functional levels. To understand these differences, we are applying cutting-edge technologies such as single cell genomics, high-throughput imaging, and cell surface profiling. These rich data enable machine learning and other integrative analysis approaches to identify the functional impact of sperm heterogeneity, thereby informing the development of our sperm-sorting technology. Such technology could help prospective parents by enhancing fertility or by diminishing the risk of transmission of diseases from the father to the child.
• Sperm function. Sperm are a highly differentiated cell type with many unique features that set it aside from other cell types, including extensive changes in activity and molecular composition as they travel through the female reproductive tract. At Ohana, we are applying a variety of tools to understand these functional changes, including high-throughput imaging, proteomics, and biophysical assays. Capitalizing on our expertise and deep understanding of these molecular and functional variations, we are currently developing:
> products to induce or inhibit hyperactivation of sperm in order to improve the success rate of assisted reproductive technologies (ARTs),
> novel, non-hormonal, long-acting, and reversible male contraceptives.