Antibody Protein Engineer

Position summary

We are seeking a motivated and innovative scientist to lead our protein engineering efforts. This role is an exciting opportunity to make a highly impactful contribution to the success of Ohana Biosciences. This individual will design engineering strategies to develop multispecific antibodies and affinity-mature and humanize antibodies. He/she will use display technologies (phage/yeast) or high-throughput transient expression methods as a tool to screen the engineered candidates and also contribute to campaigns for novel antibody discovery. Candidates should have a strong background in protein design preferably with antibodies. They will contribute to the execution of experiments in the laboratory and also be expected to manage at least one research associate. Close collaboration with project teams to develop solutions for intriguing scientific questions is key for this role.

1. Education and Experience

  • Ph.D. in Biology, Biochemistry, Bioengineering, Structural Biology or related science

  • Demonstrated track record in successfully humanizing and affinity maturing antibodies

  • Significant experience with protein modeling software

  • Deep understanding of antibody structure and function

  • Experienced in analytical techniques (DSC, DLS) to assess developability properties of antibodies

  • Excellent written and verbal communication skills as well as outstanding collaboration & interpersonal capabilities.

2. Desired Skills & Qualifications 

  • Experience with display technologies (phage/yeast) for antibody discovery and engineering

  • Experience with protein crystallography (data collection and structure determination)

  • Ability to think critically and creatively as part of a fast-paced research team, while being highly independent and self-motivated.

  • A dynamic, scientifically-excellent problem solver.

  • Possesses enthusiasm for pushing the frontiers of conventional techniques and comfort in venturing beyond one’s area of expertise.

  • An innovator who thrives in a fast-paced and evolving environment.

  • Demonstrated track record of generating data of high quality.

  • Detail-oriented and capable of multi-tasking in a small dynamic team.

  • Demonstrated ability to understand and apply scientific literature, research data and technical input, combined with use of novel approaches, to meet platform goals

Based in Cambridge, MA, Ohana is a venture-funded early-stage startup founded by Flagship Pioneering in 2015 through its venture creation engine, which founded over 40+ breakthrough companies including Seres Therapeutics, Agios, Rubius, Moderna, Editas, Denali and Codiak.  

Ohana Biosciences is pioneering field-defining science in reproductive medicine by developing cutting-edge molecular and computational technologies to drive a novel category of treatments for preventing disease, enhancing fertility, and contraception. Our enthusiasm, ambition, drive, and creativity, coupled with our unique blend of innovation, basic biology and business focus, creates an exciting entrepreneurial environment set to disrupt an area of medicine in need of substantial improvement for patients. 

For more information please check out our website

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