Research Associate/Senior Research Associate, Antibody Engineering

Ohana Biosciences is seeking an innovative Research Associate/Senior Research Associate to drive cutting-edge science in the field of reproductive biology.

We are seeking a highly motivated candidate with a passion to apply biophysical techniques to drug discovery in support of our mission to transform the field of reproductive medicine.

The Research Associate/Senior Research Associate will report to our Senior Scientist and will produce, screen, and characterize antibodies for structural and mechanistic studies. The candidate will be expected to work on a variety of protein engineering projects using cutting-edge antibody technology to optimize and generate leads for Ohana’s therapeutic and fertility programs.

Company Overview

Ohana is an early-stage biotechnology company founded in 2015 by Flagship Pioneering, which has founded over 40+ breakthrough companies, including Seres Therapeutics, Agios, Rubius, Moderna, Editas, Denali, and Codiak, since 2000.

At Ohana Biosciences, we are pioneering a new frontier in reproductive medicine. Built upon a world-leading understanding of sperm biology, Ohana has created a best-in-class proprietary platform with field-defining applications including:

  • Preventing inherited disease;

  • Delivering a highly effective, safe, reversible, non-hormonal contraceptive; and

  • Treating male infertility, traditionally ignored but responsible for half of infertility issues.

Our mission is to provide men and women the freedom to decide when to have a family and empower them to have healthy children. Join us in transforming the field of reproductive medicine and creating technologies with the power to benefit our customers and transform the lives of their patients.

What You’ll Do

  • Execute protein expression of various antigens and antibodies in mammalian and E. coli expression systems

  • Execute protein purification using a variety of different methods

  • Conduct biophysical characterization of antibody candidates using SPR, DSF, DLS, etc.

  • Perform protein crystallization screening and optimization of crystallization conditions using automated liquid handling

  • Support the evaluation of new platform technologies

  • Work both collaboratively and independently to design, plan and execute experiments that support research activities, project goals, and platform development

  • Serve as a key contributor to the discovery and development of new technologies that will transform the field of reproductive medicine

What Skills You’ll Bring

  • Minimum Bachelor’s degree in a relevant scientific discipline (biochemistry, biophysics, molecular and cell biology, or similar field). Experience working in a bio-pharmaceutical industry preferred

  • Experience with bacteria and/or mammalian culture

  • Previous use of manual and automated purification instrumentation

  • Proficiency in biochemical techniques such as SDS-PAGE, Western blot, and ELISA

  • Experience with binding techniques (SPR, Octet etc.), protein stability assays, display technologies, or crystallography a plus

  • Eagerness to learn new techniques, and comfort asking questions and seeking clarity

  • Collaborative attitude with a strong work ethic and self-motivation

  • Ability to think critically and creatively as part of a fast-paced research team, while being highly independent and self-motivated

  • Comfort handling parallel tasks and large datasets, and delivering within fast-paced deadlines

What We’ll Offer You

  • A dynamic early-stage work environment, with encouragement at all levels to be creative regarding new projects and product ideas

  • Participation in projects ranging from cutting-edge basic research to product development

  • Generous paid family leave

  • Opportunities for career development and advancement, including trainings, classes, and conferences

  • Daily on-site snacks, coffee, Bevi, and monthly catered lunches

  • Comprehensive, competitive healthcare (PPO) and dental coverage through Blue Cross Blue Shield, and vision coverage through VSP

  • Commuter benefits

  • 15 vacation days and 10+ company-paid holidays

  • 401k retirement plan, disability and life insurance

Our Culture

We are a collaborative, innovative, and enthusiastic team of 30+ employees and growing. We are highly interdisciplinary, with most scientists participating in a wide range of research projects, and creativity encouraged at all levels regarding new projects and product ideas. Our work defines the cutting edge of basic research in sperm biology.

We are located in Cambridge near the heart of America’s biotech hub. We offer an open workspace just a few blocks from the Charles River, fun perks like on-site snacks, monthly catered lunches, off-site get-togethers and other social opportunities, comprehensive, competitive health care, and more.

If you are collaborative, hard-working, and excited by the opportunity to pursue transformational science in the field of reproductive medicine, we want to talk to you.

Please email your CV or resume to

For more information please check out our website

Ohana Biosciences is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.

Note to External Recruiters: Our Human Resources department manages all open positions and candidate recruitment. We kindly ask that recruiters not contact employees or hiring managers directly to present candidates or solicit business. Please note that we will consider failure to comply with this request when determining whether to enter into a professional relationship with a recruiting agency. Please also note that submission of unsolicited resumes does not create any obligations for Ohana, implied or otherwise. If you would like to develop a recruiting relationship with us, contact

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